If solving fatigue were as simple as drinking more water and getting a good night’s sleep, most people wouldn’t still be tired. In reality, energy depends on numerous processes happening in the body every second. Hormones, enzymes, and cellular fuels all work together to keep these systems running, and changes in any part of that network can influence how the body generates, uses, and manages energy.

Providers may incorporate specific therapies into patient plans to address these underlying processes. Compounding pharmacies prepare these medications exactly as prescribed, customizing dosage form and strength to the provider’s specifications. When discussing options with your provider, factors like lab results, medical history, and individual goals help guide which therapies may be appropriate and how they could fit into a care plan. In many ways, understanding energy is like solving an equation – the variables are unique for each person. Identifying what’s draining your energy can be as important as knowing what supports it. The answers often lie in the interplay between measurable data and how you feel in daily life, creating a clearer picture of what might be at the root of fatigue.

Here are a few therapies that may come up in conversations about energy and vitality:

NAD+ is a coenzyme found in every cell and is essential for converting nutrients into ATP — the molecule cells use for energy. It also supports processes that maintain cellular function. Due to its central role in metabolism, NAD+ may be discussed as part of a plan to support cellular energy systems. Compounded NAD+ can be prepared in capsules, troches, or injectables, depending on prescription requirements.

Sermorelin is a synthetic version of a naturally occurring hormone called growth hormone–releasing hormone (GHRH). It signals the pituitary gland to produce and release growth hormone, which influences metabolism, tissue repair, and the body’s use of fuel for energy. In wellness care, sermorelin can be used within broader hormone optimization strategies when lab results indicate patterns affecting energy regulation. It is typically prescribed in an injectable form, with dosage determined by the provider.

LDN refers to naltrexone prescribed at a fraction of its standard dosage — often one-tenth or less. At these levels, it interacts with the body’s opioid receptors in a way that can temporarily block them, leading to a rebound increase in endorphin production. Endorphins influence mood, stress response, and how the body manages discomfort. While not prescribed solely for energy, LDN may be considered in plans where resilience, recovery, and daily stamina are part of the discussion.

Testosterone, estrogen, and progesterone are key hormones that influence metabolism, energy production, and mood. When lab work shows levels outside the target range, providers may recommend HRT to help restore balance. Compounded HRT can be prepared in forms such as capsules, creams, or troches to match the prescription and patient preference.‍

Determining whether a therapy is appropriate starts with the measurable facts — lab results, medical history, and personal goals. Those findings guide a provider in narrowing the options, but the true measure is how those choices fit into the rhythm of everyday life. Sometimes it’s about sustaining the focus to finish what the day demands; other times, it’s about having enough left to enjoy what comes after. The next step is working with your provider to review available options, assess their potential role in your care, and decide together on an approach that best supports your needs and goals — because we all deserve the kind of energy that carries us through the hard parts, fuels the moments we love, and leaves enough in reserve to say “yes” when life calls for more.