Estradiol is one of the three primary estrogens produced in the human body, alongside estriol and estrone. The form used in this formulation is synthesized from plant sources and is bioidentical, meaning it is structurally identical to the estradiol naturally produced in the body. Estradiol plays a key role in regulating the menstrual cycle and supporting various functions in reproductive and non-reproductive tissues. It has been studied in the context of hormone balance and menopausal health. This ingredient can be compounded into various dosage forms—including capsules, creams, troches, and suppositories—with strengths tailored to meet individual needs.